the output of tkprof is placed in the location determined by  USER_DUMP_DEST in server only.
what exactly are u trying to do?
If you are looking into performance related issues, to some extent u can use explain plan or autotrace 

mag@itloaner1_local > @c:oracleora81rdbmsadminutlxplan.sql

Table created.

mag@itloaner1_local > set autotrace on
mag@itloaner1_local > select * from dept;

    DEPTNO DNAME          LOC
---------- -------------- -------------
        10 ACCOUNTING     NEW YORK
        20 RESEARCH       DALLAS
        30 SALES          CHICAGO
        40 OPERATIONS     BOSTON

Execution Plan
----------------------------------------------------------
   0      SELECT STATEMENT Optimizer=CHOOSE
   1    0   TABLE ACCESS (FULL) OF 'DEPT'

Statistics
----------------------------------------------------------
          0  recursive calls
          4  db block gets
          2  consistent gets
          0  physical reads
          0  redo size
        678  bytes sent via SQL*Net to client
        424  bytes received via SQL*Net from client
          2  SQL*Net roundtrips to/from client
          0  sorts (memory)
          0  sorts (disk)
          4  rows processed

mag@itloaner1_local >